2026 Interoperability Guide & Vendor Checklist

Navigate the Changing Interoperability Landscape Without the Regulatory Risk

With TEFCA officially serving as the national standard and active OIG enforcement now live, choosing the wrong data exchange partner is a massive regulatory and financial liability. The momentum is undeniable: as of mid-2026, over 12,000 entities have connected to TEFCA , nearly 500 million records have been exchanged , and 60% of all U.S. hospitals are actively participating or planning to do so.

If your current software vendors are creating technical hurdles, restricting data sharing, or avoiding the TEFCA roadmap, you are risking shared liability and investing in a legacy silo.

This comprehensive guide and scorecard gives health information management (HIM) and IT leaders the exact blueprint needed to audit existing partners and objectively score new ones.

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What You’ll Learn Inside:

  • Network Comparison Matrix: A side-by-side breakdown of the agility, data scope, primary roles, and ideal use cases for TEFCA, Regional HIEs, CMS Aligned Networks, and Clinical Data Exchange.
  • The Dealbreaker Gate: How to immediately filter out high-risk vendors by checking for absolute “table stakes” compliance, such as documented Information Blocking SOPs and written contract attestations.
  • Technical Performance Benchmarks: What to look for to verify genuine FHIR R4/R5 native API access, USCDI v4/v5 support, and federally recognized identity proofing (IAL2/AAL2).
  • Operational & Cost Protections: Strategies to avoid the hidden “Interoperability Tax” by evaluating pricing models, EHR automation compatibility, and mandatory exit strategy documentation.

Streamlining Clinical Data Exchange

Smarter data, better outcomes

Discover how Moxe’s Best in KLAS Payer-Provider Data Exchange is revolutionizing healthcare by tackling administrative waste and transforming clinical data exchange. We unite payers, providers, and partners with smarter interoperability for better outcomes and reduced costs.

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